/* ==STYLE-START== */
/* ─────────────────────────────────────────────────────────────
   Arkansas Biosciences Institute — Impact Report, FY2002–FY2025

   Brand: set to match arbiosciences.org and ABI's 2026 Annual Report.
   Fira Sans for headings and text, as on the live ABI website;
   Poppins for figures. Navy #002f5f and burgundy #9d1734 match
   the current research-symposium page: blue for the
   leveraged extramural series and links, burgundy for ABI funding,
   and the red/blue/maroon helix bars as the one decorative mark.

   Direction: an instrument over a paper record. Three columns —
   navigation, analysis, and a permanent provenance margin. Four
   type roles, each carrying a meaning: Fira Sans carries the analysis,
   Poppins distinguishes numerals, and smaller source notes explain provenance.

   Color semantics are load-bearing: --accent carries the primary
   series and every verified figure, and the categorical pair is
   CVD-validated in both modes. The sequential ramp is single-hue
   and lightness-monotonic.
   ───────────────────────────────────────────────────────────── */

:root {
  color-scheme: light;
  --ground:#f5f6f8; --surface:#ffffff; --surface-2:#f6f7f9; --surface-3:#eceef2;
  --ink:#1a1a1a; --ink-2:#3b3b3b; --ink-3:#5c5f62;
  --rule:#d9dcdf; --rule-soft:#e8eaed;
  --accent:#002f5f; --accent-deep:#002f5f; --accent-wash:#e2edf6;
  --warm:#9d1734; --warm-wash:#f6e3e7; --warm-ink:#7e1d30;
  --flag:#c41e2e; --flag-wash:#fbe5e7;
  --abi-red:#cf2031; --abi-blue:#169fda; --abi-maroon:#9e253c;
  --t1:#0a6b5c; --t1-wash:#dcefec;
  --t2:#7a5c0c; --t2-wash:#f5eeda;
  --t3:#5c6a74; --t3-wash:#e9edef;
  --seq1:#e8f1f8; --seq2:#c6dcee; --seq3:#9cc3e2; --seq4:#6ca6d2;
  --seq5:#3f88bf; --seq6:#1f6aa5; --seq7:#0f4c80;
  --seg-track:#eceef2; --seg-on:#ffffff;
  --elev-1:0 1px 2px rgba(20,20,20,.06), 0 1px 1px rgba(20,20,20,.04);
  --elev-2:0 4px 16px rgba(20,20,20,.08), 0 1px 3px rgba(20,20,20,.06);
  --shadow:var(--elev-2);

  --display:"Fira Sans","Segoe UI",-apple-system,"Helvetica Neue",Arial,sans-serif;
  --sans:"Fira Sans","Segoe UI",-apple-system,system-ui,"Helvetica Neue",Arial,sans-serif;
  --figure:"Poppins","Segoe UI",-apple-system,"Helvetica Neue",Arial,sans-serif;
  /* The provenance voice. It was a monospace; ABI's brand has none, so it is
     the text face at caption size, with tabular numerals. */
  --mono:"Fira Sans","Segoe UI",-apple-system,system-ui,"Helvetica Neue",Arial,sans-serif;

  --rail:236px; --content:620px; --margin:300px; --gutter:40px; --page:1300px;
  /* 1300 - 64 pad - 236 rail - 40 gap = 960 canvas = 620 + 40 + 300, exactly.
     px not ch: 68ch was 587px in Segoe and 668px in Georgia, so the column
     width — and every line break in the report — depended on the reader. */
  --pad:32px;
  --fs-micro:12px;   /* labels, badges, eyebrows, table heads  */
  --fs-cap:13.5px;   /* captions, provenance, stat sub-lines   */
  --fs-small:15px;   /* secondary prose, table body            */
  --fs-body:16.5px;
  --grid-line:#d0d5da;  /* gridlines need their own value: at --rule-soft they
                           sat under 1.2:1 and vanished under the area band */
  --gap-mark:#8e9398;   /* the list bullet on ul.gaps                      */
  --rule-table:#d3d7db; /* row rules need more weight in a 50-row table */
  --topbar:0px;
}
@media (prefers-color-scheme: dark) {
  :root:not([data-theme="light"]) {
    color-scheme: dark;
    --ground:#0f1215; --surface:#171b20; --surface-2:#1f242a; --surface-3:#2a3037;
    --ink:#eceef0; --ink-2:#c3c8cd; --ink-3:#9aa2a9;
    --rule:#353c44; --rule-soft:#252b31;
    --grid-line:#343b43; --gap-mark:#818a92; --rule-table:#2e353c;
    --accent:#5aa9e0; --accent-deep:#7dbde9; --accent-wash:#132b3d;
    --warm:#e0768b; --warm-wash:#3a1a21; --warm-ink:#ec94a5;
    --flag:#f06a78; --flag-wash:#3a161b;
    --t1:#38b09a; --t1-wash:#10312c;
    --t2:#c9a227; --t2-wash:#2e2610;
    --t3:#859aa5; --t3-wash:#1e262b;
    /* On a dark ground a sequential ramp has to run dark-to-light, so the
       heatmap's low bin sat at the same lightness as the held-out diagonal
       fill (--surface-3) and the two could only be told apart by a faint
       hue shift. The low end is lifted clear of it here; the caption says
       "stronger color", not "darker", because the direction of the ramp is
       not the same in both themes. */
    --seq1:#13212d; --seq2:#1c3d58; --seq3:#245275; --seq4:#2d6891;
    --seq5:#3a80ad; --seq6:#519ac7; --seq7:#72b4dd;
    --seg-track:#0f1215; --seg-on:#2a3037;
    --elev-1:0 0 0 1px var(--rule), inset 0 1px 0 rgba(255,255,255,.045);
    --elev-2:0 6px 22px rgba(0,0,0,.5), 0 1px 3px rgba(0,0,0,.4);
  }
}
:root[data-theme="dark"] {
  color-scheme: dark;
  --ground:#0f1215; --surface:#171b20; --surface-2:#1f242a; --surface-3:#2a3037;
  --ink:#eceef0; --ink-2:#c3c8cd; --ink-3:#9aa2a9;
  --rule:#353c44; --rule-soft:#252b31;
  --grid-line:#343b43; --gap-mark:#818a92; --rule-table:#2e353c;
  --accent:#5aa9e0; --accent-deep:#7dbde9; --accent-wash:#132b3d;
  --warm:#e0768b; --warm-wash:#3a1a21; --warm-ink:#ec94a5;
  --flag:#f06a78; --flag-wash:#3a161b;
  --t1:#38b09a; --t1-wash:#10312c;
  --t2:#c9a227; --t2-wash:#2e2610;
  --t3:#859aa5; --t3-wash:#1e262b;
  --seq1:#13212d; --seq2:#1c3d58; --seq3:#245275; --seq4:#2d6891;
  --seq5:#3a80ad; --seq6:#519ac7; --seq7:#72b4dd;
  --seg-track:#0f1215; --seg-on:#2a3037;
  --elev-1:0 0 0 1px var(--rule), inset 0 1px 0 rgba(255,255,255,.045);
  --elev-2:0 6px 22px rgba(0,0,0,.5), 0 1px 3px rgba(0,0,0,.4);
}

/* ── base ─────────────────────────────────────────────────── */
*{box-sizing:border-box}
html{-webkit-text-size-adjust:100%;scroll-padding-top:calc(var(--topbar) + 14px)}
body{margin:0;background:var(--ground);color:var(--ink);font-family:var(--sans);
  font-size:16.5px;line-height:1.62;-webkit-font-smoothing:antialiased;
  text-rendering:optimizeLegibility;overflow-x:hidden}

h1,h2,h3,h4{font-family:var(--display);text-wrap:balance;margin:0}
h1{font-size:clamp(2.0rem,1.30rem + 2.4vw,2.85rem);font-weight:700;
  letter-spacing:-.022em;line-height:1.1;margin:0 0 20px}
h2{font-size:clamp(1.40rem,1.10rem + 1.0vw,1.85rem);font-weight:600;
  letter-spacing:-.016em;line-height:1.2;margin:0 0 .5em}
h3{font-size:1.22rem;font-weight:600;letter-spacing:-.006em;line-height:1.32;margin:0 0 .4em}
h4{font-size:.95rem;font-weight:600;margin:0 0 .3em}
/* Route changes move focus to the view heading so keyboard and screen-reader
   users land in the content. That focus is programmatic, so it must not
   paint a ring — only real keyboard focus does. */
[tabindex="-1"]:focus,[tabindex="-1"]:focus-visible{outline:none}
p,li{text-wrap:pretty}   /* browser avoids a one-word last line */
p{margin:0 0 1.05em}
a{color:inherit;text-decoration-color:color-mix(in oklab,currentColor 48%,transparent);
  text-underline-offset:3px;text-decoration-thickness:1px}
a:hover{text-decoration-color:var(--accent)}
td a,.aside a,ul.gaps a{color:var(--accent-deep);
  text-decoration-color:color-mix(in oklab,var(--accent-deep) 45%,transparent)}
:focus-visible{outline:2px solid var(--accent);outline-offset:3px}
em{font-style:italic}
code{font-family:var(--mono);font-size:1em;background:var(--surface-3);
  padding:1px 5px;border-radius:3px;color:var(--ink)}

.skip{position:fixed;left:12px;top:-64px;z-index:200;background:var(--surface);
  color:var(--ink);border:1px solid var(--accent);border-radius:4px;padding:10px 16px;
  font-size:.9rem;text-decoration:none;transition:top .14s ease}
.skip:focus{top:12px}
.vh{position:absolute!important;width:1px;height:1px;margin:-1px;padding:0;
  overflow:hidden;clip:rect(0 0 0 0);clip-path:inset(50%);white-space:nowrap;border:0;
  table-layout:fixed}   /* fixed layout: a table honors width:1px */

.eyebrow{font-family:var(--display);font-size:var(--fs-micro);letter-spacing:.16em;
  text-transform:uppercase;color:var(--accent-deep);margin:0 0 .9em;font-weight:600}
.lede{font-size:1.2rem;line-height:1.5;color:var(--ink);letter-spacing:-.004em}
.lede strong{color:var(--ink);font-weight:600}
.muted{color:var(--ink-3)}
.small{font-size:var(--fs-small)}
.micro{font-size:var(--fs-micro)}
.tnum,.n{font-variant-numeric:tabular-nums lining-nums}

/* Numerals are the one place the serif appears. A figure set in a
   serif with tabular lining numerals reads as a recorded value. */
.fig-n{font-family:var(--figure);font-variant-numeric:tabular-nums lining-nums;
  font-weight:500;letter-spacing:0}
.fig-n .unit{font-size:.56em;color:var(--ink-2);margin-left:.08em;font-weight:600}

.mt-1{margin-top:8px}.mt-2{margin-top:16px}.mt-3{margin-top:24px}
.mt-4{margin-top:32px}.mt-5{margin-top:48px}

/* ── shell ────────────────────────────────────────────────── */
.shell{max-width:var(--page);margin:0 auto;padding:0 var(--pad);
  display:grid;grid-template-columns:var(--rail) minmax(0,1fr);gap:0}

.rail{position:sticky;top:0;align-self:start;height:100vh;height:100dvh;
  padding:30px 26px 30px 0;margin-right:var(--gutter);
  border-right:1px solid var(--rule);display:flex;flex-direction:column;gap:20px;
  overflow-y:auto;overscroll-behavior:contain;scrollbar-width:thin}
.rail .brand{font-family:var(--display);font-weight:600;font-size:1rem;
  letter-spacing:-.014em;display:flex;align-items:center;gap:9px;color:var(--ink)}
.rail .brand i{width:9px;height:9px;background:var(--accent);border-radius:2px;
  font-style:normal;flex:none}
.rail .brand .bt{display:block;font-family:var(--display);font-weight:600;
  font-size:1rem;letter-spacing:-.014em;line-height:1.15}
.rail .brand .bt span{display:block;font-family:var(--mono);font-size:var(--fs-micro);
  letter-spacing:.03em;line-height:1.32;max-width:24ch;color:var(--ink-3);text-transform:uppercase;font-weight:500;
  margin-top:3px}

/* The rail is a contents ledger, not a menu: every entry carries
   its own key figure, so it is informative at rest. */
.rail-nav{display:flex;flex-direction:column;gap:1px;flex:1;min-height:0}
.rail-nav a{display:block;text-decoration:none;padding:8px 12px;border-radius:5px;
  color:var(--ink-2);border-left:2px solid transparent;transition:background .12s ease}
.rail-nav a .rl{display:block;font-size:var(--fs-small);line-height:1.25;font-weight:500}
.rail-nav a .rk{display:block;font-family:var(--mono);font-size:var(--fs-micro);
  letter-spacing:.03em;color:var(--ink-3);margin-top:2px}
.rail-nav a:hover{background:var(--surface-2)}
.rail-nav a[aria-current="page"]{background:var(--surface);border-left-color:var(--accent);
  color:var(--ink);box-shadow:var(--elev-1)}
.rail-nav a[aria-current="page"] .rl{font-weight:600}
.rail-nav a[aria-current="page"] .rk{color:var(--accent-deep)}

.rail-foot{border-top:1px solid var(--rule);padding-top:16px;display:flex;
  flex-direction:column;gap:12px}

.btn{font:inherit;font-size:var(--fs-small);font-weight:500;padding:9px 14px;
  min-height:44px;border:1px solid var(--rule);border-radius:6px;
  background:var(--surface);color:var(--ink);cursor:pointer;
  display:inline-flex;align-items:center;justify-content:center;gap:7px;
  transition:border-color .13s ease,color .13s ease}
.btn:hover:not(:disabled){border-color:var(--accent);color:var(--accent-deep)}
.btn:disabled{opacity:.45;cursor:default}
.btn.wide{width:100%}

/* ── canvas + the three-column grid ───────────────────────── */
.canvas{min-width:0;padding:0 0 8px}

.sec,.view > section{display:grid;
  grid-template-columns:minmax(0,var(--content)) minmax(0,var(--margin));
  column-gap:var(--gutter);align-content:start;
  padding:44px 0;border-bottom:1px solid var(--rule)}
.sec:last-child,.view > section:last-child,
.view > section:nth-last-child(2){border-bottom:0}
.sec > * > *:last-child,.view > section > * > *:last-child{margin-bottom:0}
/* Default: an element spans the full canvas. `.col` (and its legacy
   alias `.measure`) is the analysis column; `.aside` is the
   provenance margin beside it. */
.sec > *,.view > section > *{grid-column:1 / -1;min-width:0}
.sec > .col,.sec > .measure,
.view > section > .col,.view > section > .measure{grid-column:1;max-width:var(--content)}
.sec > .aside,.view > section > .aside{grid-column:2}
/* An aside earns the margin column only when it annotates a .col beside it.
   Following a chart or a table it has nothing to sit next to, so it would
   strand itself in column two against ~470px of empty column one. There it
   renders as an inline note attached to the exhibit above it. */
.sec > :not(.col):not(.measure) + .aside,
.view > section > :not(.col):not(.measure) + .aside{
  grid-column:1 / -1;max-width:var(--content);margin-top:18px;padding:14px 16px;
  background:var(--surface-2);border-left:2px solid var(--rule);border-radius:0 6px 6px 0}

/* The provenance margin. Not a footnote — a parallel column. */
.aside{font-family:var(--mono);font-size:var(--fs-cap);line-height:1.55;color:var(--ink-3);
  letter-spacing:.01em;padding-top:.4em;overflow-wrap:anywhere}
.aside .at{display:block;font-size:var(--fs-micro);letter-spacing:.13em;text-transform:uppercase;
  color:var(--ink-3);margin-bottom:6px;padding-bottom:6px;border-bottom:1px solid var(--rule-soft)}
.aside p{margin:0 0 .8em}
.aside p:last-child{margin-bottom:0}
.aside b,.aside strong{color:var(--ink-2);font-weight:600}
.aside a{color:var(--accent-deep);text-decoration-color:var(--rule)}

/* ── masthead ─────────────────────────────────────────────── */
.masthead{padding:36px 0 0;grid-column:1 / -1}
.masthead-intro{display:block}
.masthead-intro h1{max-width:none;margin-bottom:0}
.masthead-copy{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));
  gap:28px;margin-top:18px}
.masthead-intro .masthead-copy .sub{max-width:none;margin:0}
/* The one decorative mark: the red, blue and maroon bars of the helix in
   ABI's logo, laid on their side. */
.masthead .rule-top{height:4px;width:78px;margin-bottom:26px;border-radius:2px;
  background:linear-gradient(90deg,var(--abi-red) 0 33.3%,var(--abi-blue) 33.3% 66.6%,
    var(--abi-maroon) 66.6% 100%)}
.masthead .sub{font-family:var(--sans);font-size:clamp(1.05rem,.9rem + .7vw,1.3rem);
  font-weight:400;color:var(--ink-2);max-width:52ch;margin:.75em 0 0;line-height:1.42;
  letter-spacing:-.008em}
.dateline{display:flex;flex-wrap:wrap;gap:9px 24px;margin:28px 0 26px;
  font-family:var(--mono);font-size:var(--fs-micro);color:var(--ink-3);letter-spacing:.04em}
.dateline span{display:inline-flex;align-items:center;gap:8px}
.dateline span::before{content:"";width:5px;height:5px;border-radius:50%;
  background:var(--accent);flex:none}

/* Longer supporting notes use the report width rather than leaving a tall empty column. */
.view > section > .notes-grid{grid-column:1 / -1;max-width:none;display:grid;
  grid-template-columns:repeat(2,minmax(0,1fr));gap:16px 28px;
  margin-top:20px;padding:16px 18px;background:var(--surface-2);
  border-left:2px solid var(--rule);border-radius:0 6px 6px 0}
.notes-grid p{margin:0}
.notes-grid > .at{grid-column:1 / -1;margin:0}
.view > section > :not(.col):not(.measure) + .aside.notes-grid{max-width:none}
.view > section > .full-width{grid-column:1 / -1;max-width:none}
.full-width > p{max-width:76ch}
.definition-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:20px 28px}
.definition-grid h4{margin:0 0 8px}
.definition-grid p{margin-bottom:0}

/* ── figures (statistics) ─────────────────────────────────── */
.hero-figs{display:grid;grid-template-columns:repeat(4,1fr);
  border-top:1px solid var(--rule);border-bottom:1px solid var(--rule)}
.hero-figs>div{padding:26px 22px 26px 0;border-right:1px solid var(--rule-soft)}
.hero-figs>div:last-child{border-right:0}
.hero-figs>div+div{padding-left:22px}
.hero-figs .n{font-family:var(--figure);font-size:clamp(1.85rem,1.2rem + 1.9vw,2.6rem);
  line-height:1;letter-spacing:-.02em;display:block;font-weight:600;
  font-variant-numeric:tabular-nums lining-nums}
.unit{font-size:.56em;color:var(--ink-2);margin-left:.07em;font-weight:inherit;
  vertical-align:baseline}
.hero-figs .k{display:block;margin-top:12px;font-size:var(--fs-small);color:var(--ink-2);line-height:1.4}
.hero-figs .accent{color:var(--accent-deep)}

.statgrid{display:grid;gap:1px;background:var(--rule-soft);border:1px solid var(--rule);
  border-radius:8px;overflow:hidden;margin-top:28px}

.statgrid.c4{grid-template-columns:repeat(4,1fr)}
.statgrid.c3{grid-template-columns:repeat(3,1fr)}
.statgrid.c2{grid-template-columns:repeat(2,1fr)}
.statgrid.c1{grid-template-columns:1fr}
.statgrid>div{background:var(--surface);padding:20px 18px;
  display:grid;grid-template-rows:auto 1fr auto}
.statgrid .n{font-family:var(--figure);font-size:1.8rem;line-height:1;font-weight:600;
  letter-spacing:-.004em;font-variant-numeric:tabular-nums lining-nums;display:block}
.statgrid .k{display:block;margin-top:10px;align-self:start;font-size:var(--fs-small);color:var(--ink-2);line-height:1.4}
.statgrid .s{display:block;margin-top:5px;font-size:var(--fs-cap);color:var(--ink-3);line-height:1.45}

/* ── figures (charts) ─────────────────────────────────────── */
figure{margin:32px 0 0;background:var(--surface);border:1px solid var(--rule);
  border-radius:10px;overflow:hidden;box-shadow:var(--elev-1)}
figure .fig-head{padding:18px 22px 15px;border-bottom:1px solid var(--rule-soft);
  display:flex;justify-content:space-between;align-items:baseline;gap:18px;flex-wrap:wrap}
figure .fig-head h3{margin:0}
figure .fig-head .hint{font-family:var(--mono);font-size:var(--fs-cap);color:var(--ink-3);
  letter-spacing:.04em}
.fig-body{padding:20px 22px 10px}
figcaption{padding:15px 22px 17px;border-top:1px solid var(--rule-soft);
  font-size:var(--fs-small);line-height:1.55;color:var(--ink-2);background:var(--surface-2);
  max-width:none}
figcaption > *{max-width:72ch}
/* The source line is the credibility device the whole report rests on, so it
   is set at full body contrast rather than as fine print. */
figcaption .prov{display:block;margin-top:8px;font-family:var(--mono);font-size:var(--fs-cap);
  letter-spacing:.03em;color:var(--ink-2)}
.legend{display:flex;flex-wrap:wrap;gap:9px 20px;align-items:center;font-size:var(--fs-small);
  color:var(--ink-2);margin-bottom:4px}
.legend i{width:20px;height:3px;border-radius:2px;display:inline-block;margin-right:7px;
  vertical-align:middle}

/* ── charts ───────────────────────────────────────────────── */
.chart{position:relative;width:100%}
.chart svg{display:block;width:100%;height:auto;overflow:visible}
.chart:focus-visible{outline:2px solid var(--accent);outline-offset:4px;border-radius:6px}
.gridline{stroke:var(--grid-line);stroke-width:1}
.axis-txt{font-family:var(--mono);font-size:12px;fill:var(--ink-3);
  font-variant-numeric:tabular-nums lining-nums}
.axis-line{stroke:var(--rule);stroke-width:1}
.bar-label{font-family:var(--sans);font-size:13px;fill:var(--ink-2)}
.bar-value{font-family:var(--mono);font-size:12.5px;fill:var(--ink-2);
  font-variant-numeric:tabular-nums lining-nums}
.cell-num{font-family:var(--mono);font-size:12px;
  font-variant-numeric:tabular-nums lining-nums}
.bar-sub{font-family:var(--sans);font-size:12px;fill:var(--ink-2)}
.crosshair{stroke:var(--ink-3);stroke-width:1;stroke-dasharray:3 3;opacity:0}
.hit{fill:transparent;cursor:crosshair}
.tip{position:absolute;pointer-events:none;opacity:0;z-index:50;background:var(--surface);
  border:1px solid var(--rule);border-radius:7px;padding:10px 12px;font-size:var(--fs-small);
  line-height:1.5;box-shadow:var(--elev-2);min-width:158px;transition:opacity .1s ease}
.tip .t-fy{font-family:var(--mono);font-size:var(--fs-micro);letter-spacing:.06em;color:var(--ink-3);
  display:block;margin-bottom:6px}
.tip .t-row{display:flex;justify-content:space-between;gap:18px}
.tip .t-row b{font-variant-numeric:tabular-nums lining-nums;font-weight:600}

/* ── tables ───────────────────────────────────────────────── */
.tbl-scroll{overflow-x:auto;position:relative;scrollbar-width:thin}
table{border-collapse:collapse;width:100%;font-size:var(--fs-small)}
th,td{text-align:left;padding:10px 12px 10px 0;border-bottom:1px solid var(--rule-soft);
  font-variant-numeric:tabular-nums lining-nums;vertical-align:top}
th{font-family:var(--mono);font-size:var(--fs-micro);letter-spacing:.06em;text-transform:uppercase;
  color:var(--ink-3);font-weight:500;border-bottom:1px solid var(--rule);white-space:nowrap;
  position:relative}
th.sortable{cursor:pointer;user-select:none}
th.sortable:hover{color:var(--ink)}
th.sortable::after{content:"";opacity:.35;margin-left:6px}
th[aria-sort="ascending"]::after{content:"▲";opacity:.85;color:var(--accent-deep)}
th[aria-sort="descending"]::after{content:"▼";opacity:.85;color:var(--accent-deep)}
td.num,th.num{text-align:right;padding-right:0}
td.num{font-variant-numeric:tabular-nums lining-nums}
/* Both cell types: a row-head cell in the last row used to keep a rule the
   rest of its row had dropped, leaving a hairline stub under the first
   column of every table that carries row heads. */
tbody tr:last-child td,tbody tr:last-child th{border-bottom:0}
tbody tr:nth-child(even){background:color-mix(in oklab,var(--ink) 3%,transparent)}
tbody tr:hover{background:var(--accent-wash)}
tfoot td{border-top:1px solid var(--rule);border-bottom:0;font-weight:600;padding-top:12px}
.tbl-wrap{background:var(--surface);border:1px solid var(--rule);border-radius:10px;
  padding:6px 20px;box-shadow:var(--elev-1);margin-top:24px}

/* ── controls ─────────────────────────────────────────────── */
.controls{display:flex;flex-wrap:wrap;gap:12px;align-items:center;margin:28px 0 8px;
  padding:16px 18px;background:var(--surface);border:1px solid var(--rule);
  border-radius:10px;box-shadow:var(--elev-1)}
.controls input[type=search],.controls select{font:inherit;font-size:var(--fs-small);
  padding:0 11px;min-height:44px;border:1px solid var(--rule);border-radius:6px;
  background:var(--ground);color:var(--ink)}
.controls input[type=search]{flex:1 1 240px;min-width:170px}
.controls label{font-family:var(--mono);font-size:var(--fs-micro);color:var(--ink-3);
  letter-spacing:.06em;text-transform:uppercase}
.controls .grp{display:flex;align-items:center;gap:8px}
.controls .count{margin-left:auto;font-family:var(--mono);font-size:var(--fs-cap);color:var(--ink-3)}

/* ── badges ───────────────────────────────────────────────── */
.chip{font-family:var(--mono);font-size:var(--fs-micro);letter-spacing:.04em;padding:3px 7px;
  border-radius:4px;background:var(--surface-3);color:var(--ink-2);white-space:nowrap;
  display:inline-block}
/* a status reads as prose and may wrap; an identifier may not */
.chip.wrap{white-space:normal;line-height:1.35}
.era{font-family:var(--mono);font-size:var(--fs-micro);color:var(--ink-3);
  white-space:nowrap}
/* An award id or a fiscal-year range must never break mid-token. The title
   column links to the same registries, though, so it is exempted — a trial
   name held on one line overflows its cell instead of wrapping. */
td a[href*="reporter.nih"],td a[href*="nsf.gov"],td a[href*="usaspending"],
td a[href*="clinicaltrials"],.chip,td .tnum{white-space:nowrap}
td:first-child a,td[data-p="1"] a,td.dt-title a{white-space:normal;overflow-wrap:anywhere}

/* ── callouts ─────────────────────────────────────────────── */
.callout{background:var(--accent-wash);border:1px solid var(--rule);
  border-left:3px solid var(--accent);border-radius:8px;padding:19px 22px;margin-top:26px}
.callout.warn{background:var(--flag-wash);border-left-color:var(--flag)}
/* A note about what a figure covers reads differently from a warning, so it
   takes the counter-hue rather than the alert one. */
.callout.note{background:var(--warm-wash);border-left-color:var(--warm)}
.callout.note .eyebrow{color:var(--warm-ink)}
.callout p:last-child{margin-bottom:0}
.callout .eyebrow{color:var(--accent-deep)}
.callout.warn .eyebrow{color:var(--flag)}

ul.gaps{list-style:none;padding:0;margin:22px 0 0}
ul.gaps li{padding:13px 0 13px 28px;border-bottom:1px solid var(--rule-soft);
  position:relative;font-size:var(--fs-small);line-height:1.55}
ul.gaps li:last-child{border-bottom:0}
ul.gaps li::before{content:"";position:absolute;left:4px;top:calc(13px + .78em);width:9px;
  height:2px;background:var(--gap-mark);border-radius:1px}
ul.gaps b{color:var(--ink);font-weight:600}

/* ── view pager ───────────────────────────────────────────── */
.pager{grid-column:1 / -1;display:flex;gap:14px;justify-content:space-between;
  padding:34px 0 0;border-top:1px solid var(--rule);margin-top:8px;
  max-width:calc(var(--content) + var(--gutter) + var(--margin))}
.pager a{flex:1 1 0;min-width:0;text-decoration:none;padding:16px 18px;
  border:1px solid var(--rule);border-radius:9px;background:var(--surface);
  box-shadow:var(--elev-1);transition:border-color .13s ease}
.pager a:hover{border-color:var(--accent)}
.pager a.next{text-align:right}
.pager .pk{display:block;font-family:var(--mono);font-size:var(--fs-micro);letter-spacing:.12em;
  text-transform:uppercase;color:var(--ink-3);margin-bottom:5px}
.pager .pl{display:block;font-family:var(--display);font-weight:600;font-size:1rem;
  letter-spacing:-.012em;color:var(--ink)}
.pager .spacer{flex:1 1 0}
.pager:has(.spacer) a{flex:1 1 100%}

footer{grid-column:1 / -1;max-width:calc(var(--content) + var(--gutter) + var(--margin));
  padding:44px 0 64px;font-size:var(--fs-small);line-height:1.6;
  color:var(--ink-3);border-top:1px solid var(--rule);margin-top:8px}
footer p{max-width:76ch}

/* ── mobile top bar + contents sheet ──────────────────────── */
.topbar{display:none;position:sticky;top:0;z-index:60;background:var(--ground);
  border-bottom:1px solid var(--rule);
  padding:0 max(16px,env(safe-area-inset-left)) 0 max(16px,env(safe-area-inset-right))}
.topbar .tb{display:flex;align-items:center;gap:12px;min-height:56px;
  max-width:var(--page);margin:0 auto}
.topbar .tt{flex:1;min-width:0;font-family:var(--display);font-weight:600;font-size:1rem;
  letter-spacing:-.014em;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}
.topbar .tt small{display:block;font-family:var(--mono);font-size:var(--fs-micro);font-weight:400;
  letter-spacing:.1em;text-transform:uppercase;color:var(--ink-3)}
.icon-btn{font:inherit;font-size:var(--fs-small);font-weight:500;min-height:44px;min-width:44px;
  padding:0 13px;border:1px solid var(--rule);border-radius:7px;background:var(--surface);
  color:var(--ink);cursor:pointer;display:inline-flex;align-items:center;gap:7px;flex:none}

.sheet{position:fixed;inset:0;z-index:100;display:none}
.sheet[open]{display:block}
.sheet .scrim{position:absolute;inset:0;background:rgba(8,14,18,.5);
  animation:fade .18s ease}
.sheet .panel{position:absolute;inset:0;background:var(--ground);
  display:flex;flex-direction:column;
  padding:max(14px,env(safe-area-inset-top)) 18px max(18px,env(safe-area-inset-bottom));
  animation:rise .22s cubic-bezier(.2,.7,.3,1)}
.sheet .sh{display:flex;align-items:center;justify-content:space-between;gap:12px;
  padding-bottom:14px;border-bottom:1px solid var(--rule)}
.sheet .sh b{font-family:var(--display);font-size:1.05rem;font-weight:600;letter-spacing:-.014em}
.sheet .slist{flex:1;overflow-y:auto;padding:10px 0;display:flex;flex-direction:column;gap:2px}
.sheet .slist a{display:flex;align-items:baseline;justify-content:space-between;gap:16px;
  text-decoration:none;padding:14px 14px;border-radius:8px;color:var(--ink-2);min-height:44px}
.sheet .slist a .rl{font-size:1rem;font-weight:500;color:var(--ink)}
.sheet .slist a .rk{font-family:var(--mono);font-size:var(--fs-cap);color:var(--ink-3);
  white-space:nowrap;text-align:right}
.sheet .slist a[aria-current="page"]{background:var(--surface);box-shadow:var(--elev-1)}
.sheet .slist a[aria-current="page"] .rk{color:var(--accent-deep)}
.sheet .sfoot{border-top:1px solid var(--rule);padding-top:16px;display:flex;
  flex-direction:column;gap:12px}
@keyframes fade{from{opacity:0}to{opacity:1}}
@keyframes rise{from{opacity:0;transform:translateY(14px)}to{opacity:1;transform:none}}

/* ── motion: view entry ───────────────────────────────────── */
.view{display:block}
.view.leaving{opacity:0;transition:opacity .09s ease}
.view.entering > *{opacity:0;transform:translateY(8px)}
.view.entered > *{opacity:1;transform:none;
  transition:opacity .22s ease,transform .22s cubic-bezier(.2,.7,.3,1)}
.view.entered > :nth-child(1){transition-delay:0ms}
.view.entered > :nth-child(2){transition-delay:24ms}
.view.entered > :nth-child(3){transition-delay:48ms}
.view.entered > :nth-child(4){transition-delay:72ms}
.view.entered > :nth-child(5){transition-delay:96ms}
.view.entered > :nth-child(6){transition-delay:120ms}
.view.entered > :nth-child(7){transition-delay:144ms}
.view.entered > :nth-child(8){transition-delay:168ms}

/* ── responsive ───────────────────────────────────────────── */
@media (max-width:1279px){
  :root{--margin:0px}
  .sec,.view > section{grid-template-columns:minmax(0,1fr)}
  .sec > .aside,.view > section > .aside{grid-column:1;margin-top:18px;padding:14px 16px;
    background:var(--surface-2);border-left:2px solid var(--rule);border-radius:0 6px 6px 0;
    max-width:var(--content)}
  .aside .at{border-bottom-color:var(--rule)}
}
@media (max-width:1099px){
  .masthead-copy{grid-template-columns:minmax(0,1fr);gap:14px}
  .masthead-intro h1{max-width:25ch}
  .masthead-intro .sub{max-width:68ch}
}
@media (max-width:1023px){
  :root{--pad:24px;--topbar:56px}
  .shell{grid-template-columns:minmax(0,1fr)}
  .rail{display:none}
  .topbar{display:block}
  .canvas{padding-top:4px}
  .masthead{padding-top:34px}
  .sec,.view > section{padding:36px 0}
}
@media (max-width:900px){
  .hero-figs{grid-template-columns:repeat(2,1fr)}
  .hero-figs>div{padding:22px 18px 22px 0}
  .hero-figs>div+div{padding-left:0}
  .hero-figs>div:nth-child(even){padding-left:18px;border-right:0}
  .hero-figs>div:nth-child(-n+2){border-bottom:1px solid var(--rule-soft)}
  .statgrid.c4{grid-template-columns:repeat(2,1fr)}
  /* a 3-up grid collapsing to 2 leaves a filled, empty third cell */
  .statgrid.c3{grid-template-columns:1fr}

  .pager{flex-direction:column}
  .pager a.next{text-align:left}
}
@media (max-width:620px){
  :root{--pad:18px}
  .sec,.view > section{padding:30px 0}
  .view > section > .notes-grid{grid-template-columns:minmax(0,1fr);gap:14px}
  .definition-grid{grid-template-columns:minmax(0,1fr)}
  .statgrid.c4,.statgrid.c2{grid-template-columns:repeat(2,1fr)}
  .statgrid.c3{grid-template-columns:1fr}
  .statgrid>div{padding:16px 14px}

  .hero-figs>div{padding:18px 12px 18px 0}
  .hero-figs>div:nth-child(even){padding-left:12px}
  .fig-body{padding:16px 14px 8px}
  figure .fig-head{padding:16px 16px 13px}
  figcaption{padding:14px 16px 15px}
  .controls{padding:14px;gap:10px}
  .controls input[type=search]{flex:1 1 100%}
  .controls .grp{flex:1 1 calc(50% - 5px);min-width:0}
  .controls .grp select{flex:1;min-width:0}
  .controls .count{margin-left:0;flex:1 1 100%}
  .tbl-wrap{padding:6px 14px}
  .callout{padding:16px 17px}
}
@media screen and (max-width:360px){
  figure:has(#collabFig) .fig-body{padding-left:4px;padding-right:4px}
}

@media (max-width:620px){
  /* In card mode each row is a flex container. A flex item defaults to
     min-width:auto, so a long journal title could not shrink below its
     min-content width and pushed the page 49px sideways. */
  .card-table tr,.card-table td,.card-table td > *{min-width:0}
}
@media (pointer:coarse){
  td a,.tbl-wrap td a{display:inline-block;padding-block:12px}
}
@media (prefers-reduced-motion:reduce){
  *,*::before,*::after{animation-duration:.01ms!important;animation-iteration-count:1!important;
    transition-duration:.01ms!important;scroll-behavior:auto!important}
  .view.entering > *,.view.entered > *{opacity:1;transform:none}
}

/* ── print ────────────────────────────────────────────────── */
#printOnly{display:none}
@media print{
  #printOnly{display:block}
  .shell{display:none!important}
  .print-cover{padding:0 0 26px;border-bottom:2px solid var(--ink);margin-bottom:26px;
    break-after:page}
  .print-cover h1{font-size:30pt;margin:.24em 0 .5em;max-width:16ch}
  .print-cover .lede{max-width:56ch;margin-bottom:2.2em}
  .print-cover .hero-figs{grid-template-columns:repeat(2,1fr);margin-bottom:2.4em}
  .print-cover .muted{margin:0}
  .print-view{break-before:page}
  #printOnly > .print-view:first-of-type{break-before:auto}
  .print-rule{font-family:var(--mono);font-size:8.5pt;letter-spacing:.16em;
    text-transform:uppercase;color:var(--ink-3);border-bottom:1px solid var(--rule);
    padding-bottom:7px;margin:0 0 20px;font-weight:500}
  .print-view .pager,.print-view .tip{display:none!important}
  .print-view .masthead{padding-top:0}
  @page{margin:16mm 14mm 18mm}
}
@media print{
  /* :root:root outranks both :root[data-theme="dark"] and the
     prefers-color-scheme block, so printing from dark mode still
     yields a white page. */
  :root:root{color-scheme:light;
    --ground:#fff;--surface:#fff;--surface-2:#fafbfc;--surface-3:#f0f3f5;
    --ink:#111;--ink-2:#3a3a3a;--ink-3:#555;--rule:#b9c2c9;--rule-soft:#d8dee3;
    --accent:#002f5f;--accent-deep:#002f5f;--accent-wash:#e2edf6;
    --warm:#9d1734;--warm-wash:#f6e3e7;--warm-ink:#7e1d30;--flag:#8c1032;--flag-wash:#fbeef2;
    --t1:#0a5f52;--t1-wash:#eef5f3;--t2:#63490a;--t2-wash:#f7f2e4;
    --t3:#555;--t3-wash:#f0f2f4;--grid-line:#c3ccd2;--gap-mark:#777;
    --seq1:#e8f1f8;--seq2:#c6dcee;--seq3:#9cc3e2;--seq4:#6ca6d2;
    --seq5:#3f88bf;--seq6:#1f6aa5;--seq7:#0f4c80;
    --elev-1:none;--elev-2:none;--shadow:none;--margin:0px;--pad:0px}
  .topbar,.rail,.sheet,.controls,.btn,.icon-btn,.pager,.skip{display:none!important}
  .shell{grid-template-columns:1fr;max-width:none}
  .masthead-intro{display:block}
  .masthead-copy{display:block}
  .masthead-intro .masthead-copy .sub{margin-top:.75em;max-width:76ch}
  .masthead-intro h1{max-width:none;margin-bottom:.5em}
  .sec,.view > section{grid-template-columns:1fr;padding:26px 0;break-inside:auto}
  .sec > .col,.sec > .measure,.view > section > .col,.view > section > .measure{max-width:none}
  .sec > .aside,.view > section > .aside{grid-column:1;background:none;
    border-left:2px solid var(--rule);padding:8px 0 8px 12px;margin-top:12px}
  body{font-size:10pt;background:#fff}
  figure,.callout,.statgrid,.hero-figs,.tbl-wrap{break-inside:avoid}
  h1,h2,h3{break-after:avoid}
  .view{display:block!important;opacity:1!important}
  .view > *{opacity:1!important;transform:none!important}
  thead{display:table-header-group}
  tr{break-inside:avoid}
}

/* ── the pager's hidden attribute must actually hide it ─────
   The table engine retires the pager whenever a filtered result
   fits on one page (paintPagers: `if (!all && total <= per)`),
   sets p.hidden = true and returns BEFORE restating the position
   readout. But the engine's own `.dt-pager{display:flex}` is
   author CSS, and it outranks the user-agent `[hidden]` rule, so
   the bar stayed on screen still wearing the numbers from before
   the filter. Searching "proteomics" on the portfolio left the
   reader reading "Showing 1-24 of 24 rows" directly above
   "Page 1 of 56 - showing 1-50 of 2,754", with a live Next and a
   56-entry jump menu paging a result set that no longer existed.
   The engine's intent is already correct; only the cascade was
   wrong, so make hidden bind rather than repaint dead controls. */
.dt-pager[hidden],
.dt .dt-pager[hidden],
.dt .dt-count[hidden]{display:none!important}

/* ── ABI brand: logo, links out, credit line ─────────────────
   The logo leads the rail the way it leads arbiosciences.org. It has
   a light and a dark cut; only the one that matches the theme shows. */
@font-face{font-family:'Fira Sans';font-style:italic;font-weight:400;font-display:swap;src:url(fonts/FiraSans-400i.woff2) format('woff2');unicode-range:U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD}
@font-face{font-family:'Fira Sans';font-style:normal;font-weight:400;font-display:swap;src:url(fonts/FiraSans-400.woff2) format('woff2');unicode-range:U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD}
@font-face{font-family:'Fira Sans';font-style:normal;font-weight:500;font-display:swap;src:url(fonts/FiraSans-500.woff2) format('woff2');unicode-range:U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD}
@font-face{font-family:'Fira Sans';font-style:normal;font-weight:600;font-display:swap;src:url(fonts/FiraSans-600.woff2) format('woff2');unicode-range:U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD}
@font-face{font-family:'Poppins';font-style:normal;font-weight:500;font-display:swap;src:url(fonts/Poppins-500.woff2) format('woff2');unicode-range:U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD}
@font-face{font-family:'Poppins';font-style:normal;font-weight:600;font-display:swap;src:url(fonts/Poppins-600.woff2) format('woff2');unicode-range:U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD}
@font-face{font-family:'Poppins';font-style:normal;font-weight:700;font-display:swap;src:url(fonts/Poppins-700.woff2) format('woff2');unicode-range:U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD}
.rail .brand{flex-direction:column;align-items:flex-start;gap:10px;text-decoration:none;
  padding:2px 0 4px}
.rail .brand .logo{display:block;width:150px;height:auto}
.rail .brand .logo-dark{display:none}
.rail .brand .bt{font-family:var(--display);font-weight:600;font-size:var(--fs-micro);
  letter-spacing:.2em;text-transform:uppercase;color:var(--ink-2);line-height:1.3}
.rail .brand .bt span{font-family:var(--display);letter-spacing:.2em;color:var(--ink-3);
  font-weight:500;margin-top:2px}
.rail-link{font-size:var(--fs-cap);color:var(--accent-deep);text-align:center;
  text-decoration-color:color-mix(in oklab,var(--accent-deep) 45%,transparent)}
.rail-credit,.sheet-credit{margin:0;font-size:var(--fs-micro);line-height:1.5;color:var(--ink-3)}
.rail-credit a,.sheet-credit a{color:var(--ink-2)}
.sheet-credit{padding:14px 4px 4px;border-top:1px solid var(--rule-soft);margin-top:10px}
.topbar .tb-mark{width:22px;height:22px;flex:none}

.site-credit{grid-column:1 / -1;max-width:calc(var(--content) + var(--gutter) + var(--margin));
  margin-top:40px;padding:22px 0 56px;border-top:1px solid var(--rule-soft);
  font-size:var(--fs-cap);line-height:1.6;color:var(--ink-3)}
.site-credit p{margin:0}
.site-credit a{color:var(--ink-2)}

@media (prefers-color-scheme: dark){
  :root:not([data-theme="light"]) .rail .brand .logo-light{display:none}
  :root:not([data-theme="light"]) .rail .brand .logo-dark{display:block}
}
[hidden]{display:none!important}
[data-jump]{scroll-margin-top:10px}
.hero-figs .k a{color:inherit;text-decoration-thickness:1px;text-underline-offset:3px}
:root[data-theme="dark"] .rail .brand .logo-light{display:none}
:root[data-theme="dark"] .rail .brand .logo-dark{display:block}
@media print{
  .view .site-credit{display:none}
  .dt-toast{display:none!important}
}
/* ==STYLE-END== */